3,4-(methylenodioxy)aniline as precursor to thiazolidinones

3,4-(methylenodioxy)aniline as precursor to thiazolidinones

Masteloto, Hellen G.; Drawanz, Bruna B.; Siqueira, Geonir M.; Cunico*, Wilson

Abstract:

The thiazolidinones are five-membered heterocyclic compounds that show a diverse range of biological activities, for example, as antitumor, antidiabetes, antitubercular and anti-hepatitis C virus. The main synthetic routes to thiazolidin-4- ones involves a three component reaction (an aldehyde or ketone, a primary amine or hydrazine and the mercaptoacetic acid) either in an one- or two-step process. This work has as objective, report the synthesis of new thiazolidinones 4a-r arising from the reaction of 3,4-(methylenedioxy)aniline 1 with substituted arenealdehydes 2a-r and mercaptoacetic acid 3.

The thiazolidinones are five-membered heterocyclic compounds that show a diverse range of biological activities, for example, as antitumor, antidiabetes, antitubercular and anti-hepatitis C virus. The main synthetic routes to thiazolidin-4- ones involves a three component reaction (an aldehyde or ketone, a primary amine or hydrazine and the mercaptoacetic acid) either in an one- or two-step process. This work has as objective, report the synthesis of new thiazolidinones 4a-r arising from the reaction of 3,4-(methylenedioxy)aniline 1 with substituted arenealdehydes 2a-r and mercaptoacetic acid 3.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_201391411507

Referências bibliográficas

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Como citar:

Masteloto, Hellen G.; Drawanz, Bruna B.; Siqueira, Geonir M.; Cunico*, Wilson; "3,4-(methylenodioxy)aniline as precursor to thiazolidinones", p-76-76. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201391411507