janeiro 2015 vol. 1 num. 3 - International Symposium on Crystallography
Abstract - Open Access.
SYNTHESIS AND CHARACTERIZATION OF FLUBENDAZOLE COCRYSTALS
dos Santos, C. R. M.; Carvalho, F. M. S.; Antonio, S. G.; Paiva-Santos, C. O.; Bou-Chacra, N. A.; Ferreira, F. F.; Flores, R. L. R.; de Araujo, G. L. B.;
Background/problem statement: Flubendazole (FBZ) has a great potential for the treatment of lymphatic filariasis in humans, but is poorly absorbed in the current formulations available due its low solubility in water. Objective: The present work describes the synthesis and characterization of FBZ cocrystals in combination with carboxilics acids.Methods: Mechanochemical liquid-assisted grinding method was used to obtain mixtures corresponding to 1:1 stoichiometric ratios of flublendazole and the cocrystal former. The mixtures were evaluated by X-ray powder diffraction (Bruker D8 Advance). Results: The XRPD patterns (Fig.1) show a potential cocrystal formation with maleic acid and no evidence of cocrystal with aspirin as former.Conclusions: The combination of flubendazole with maleic acid with application of mechanosynthesis has great potential to obtain cocrystals and can represent a new way for the development of a new oral solid dosage form containing flubendazole.
dos Santos, C. R. M.; Carvalho, F. M. S.; Antonio, S. G.; Paiva-Santos, C. O.; Bou-Chacra, N. A.; Ferreira, F. F.; Flores, R. L. R.; de Araujo, G. L. B.; "SYNTHESIS AND CHARACTERIZATION OF FLUBENDAZOLE COCRYSTALS", p. 16 . In: Proceedings of the International Symposium on Crystallography [Blucher Physics Proceedings, v.1, n.3].
São Paulo: Blucher,
ISSN 2358-2359, DOI 10.5151/phypro-sic100-016
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