Abstract:

There are many studies describing the biologic properties of 5-arylidene-2,4- thiazolidinediones like: aldose reductase inhibitors, antibacterial, anti-cancer, antioxidant and antifungal. For this aldol condensation, the literature reports several methods such as: KOH or piperidine in reflux of ethanol or toluene, polyethene glycol (PEG-300) in reflux without base. These conditions take some hours of reaction. Nowadays, several studies have been done looking for new methods that increase the speed of some reactions. The literature shows the emerging use of microwave irradiation to promote some synthesis, among them, the synthesis of 5-arylidene-2,4-thiazolidinediones between 10-30 minutes. In the same way, other good possibility is the use of sonochemistry once the ultrasound irradiation produces the cavitation effect that accelerates several synthetic reactions. So, the aim of this work was describe the capacity of ultrasound irradiation methodology to synthesis of 5- arilydenethiazolidine-2,4-diones.