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SCNS. 12. Effects of trimetazidine on pilocarpine-induced convulsions in mice: behavioral changes and glutamatergic system modulation

PINHEIRO, T.F.M.; LEMOS, J.C.; BEZERRA, M.M.; AGUIAR, L.M.V.; FILHO, G.C.;

Abstract:

Epilepsy is one of the most common and serious neurological conditions, affecting more than 50 million people worldwide. The current clinically available antiepileptic drugs are associated with a variety of side-effects and chronic toxicity. Adverse effects associated with these agents are the main limitation for their long-term use. Therefore, the development of new antiepileptic agent with improved efficacy and minimal adverse effects is very important. Trimetazidine (TMZ) is a lipophilic piperazine derivative, a drug of interest in ischemic diseases. It has demonstrated anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties in various experimental animal models. The aim of this study was to investigate the antioxidant effect of trimetazidine on pilocarpine-induced seizures in mice.

Abstract:

Palavras-chave: trimetazidine, seizure, glutamate,

Palavras-chave:

DOI: 10.5151/isnm-sine17

Referências bibliográficas
Como citar:

PINHEIRO, T.F.M.; LEMOS, J.C.; BEZERRA, M.M.; AGUIAR, L.M.V.; FILHO, G.C.; "SCNS. 12. Effects of trimetazidine on pilocarpine-induced convulsions in mice: behavioral changes and glutamatergic system modulation", p. 22 . In: In I International Symposium in Neuroscience Meeting, 2013 [Blucher Neuroscience Proceedings n.1 v.1]. São Paulo: Blucher, 2014.
ISSN 2357-772x, DOI 10.5151/isnm-sine17

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