fevereiro 2015 vol. 1 num. 2 - XX Congresso Brasileiro de Engenharia Química
Artigo - Open Access.
PHARMACEUTICAL AEROSOLS DEPOSITION DURING INHALATION, BREATH HOLDING AND EXHALATION USING CFD
In the last decades, the air pollution lead to an increase in the impact of the particle deposition in human lungs, especially with respect to respiratory diseases. Since the airway bifurcations are difficult regions to investigate, the Computational Fluid Dynamics (CFD) can be an alternative to the study of pharmaceutical aerosols that are used to the treatment of some respiratory diseases. In this study, the particle deposition was analyzed in a three-dimensional model of four ramifications or three bifurcations during three different situations: inhalation, exhalation and breath holding. The aim was to verify the medical recommendations to hold the breath during few seconds after inhale the pharmaceutical aerosols by comparison of the deposition of particles with 5 µm diameter. The numerical results of deposition during inhalation was compared to experimental data from the literature and showed good agreements. The results showed that the number of collected aerosols in the airway walls was greater for the situation of breath holding, which, in fact, confirms the medical recommendations. During the exhalation, the particles leave the domain, which would not be an interesting action after inhale the medicines.
-  BENNET, W. D. Targeting Respiratory Drug Delivery with Aerosols Boluses. Journal of Aerosol Medicine, v. 4, n. 2, p. 69-78, 199
-  BRICKUS, L. S. R.; AQUINO NETO, F. R. A Qualidade do Ar e de Interiores e a Química. Química Nova, v. 22, n. 1, p. 65-74, 1999.
-  FERZIGER, J. H.; PERIĆ, M. Computational Methods of Fluid Dynamics. Berlin: Springer Verlag, 2002.
-  FORTUNA, A. O. Técnicas Computacionais para Dinâmicas dos Fluidos: Conceitos Básicos e Aplicações. São Paulo: Edusp, 2012.
-  KIM, C. S.; FISHER, D. M. Deposition Characteristics of Aerosol Particles in Sequentially Bifurcating Airway Models. Aerosol Science and Technology, v. 31, n. 2-3, p. 198-220, 1999.
-  LONGEST, P. W.; VINCHURKAR, S. Effects of Mesh Style and Grid Convergence on Particle Deposition in Bifurcating Airway with Comparisons to Experimental Data. Mechanical Engineering Andamp; Physics, v. 29, n. 3, p. 350-366, 2007.
-  MÖLLER, W.; MEYER, G.; KREYLING, W. G.; BENNET, W. D. Left-to-Right Asymmetry of Aerosol Deposition After Shallow Bolus Inhalation Depends on Lung Ventilation. Journal of Aerosol Medicine and Pulmonary Drug Delivery, v. 22, n. 4, p. 333-339, 2009.
-  MORSI, S. A.; ALEXANDER, A. J. An Investigation of Particle Trajectories in Two-Phase Flow Systems. Journal of Fluid Mechanics, v. 55, n. 2, p. 193-20
-  WEIBEL, E. R. Morphometry of the Human Lung, New York: Springer Verlag, 1963.
-  ZHANG, Z.; KLEINSTREUER, C.; KIM, C. S. Gas-Solid Two-Phase Flow in a Triple Bifurcation Lung Airway Model. International Journal of Multiphase Flow, v. 28, n. 6, p. 1021-1046, 2002.
AUGUSTO, L. L. X.; LOPES, G. C.; GONÇALVES, J. A. S.; "PHARMACEUTICAL AEROSOLS DEPOSITION DURING INHALATION, BREATH HOLDING AND EXHALATION USING CFD", p. 5985-5992 . In: Anais do XX Congresso Brasileiro de Engenharia Química - COBEQ 2014 [= Blucher Chemical Engineering Proceedings, v.1, n.2].
São Paulo: Blucher,
ISSN 2359-1757, DOI 10.5151/chemeng-cobeq2014-1489-19037-152591
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