Abstract:

Nanocatalysis has arisen in the last few years as a bridge between heterogeneous and homogenous catalysis. Metals deposited on the surface of magnetite nanomaterials have been used with the aim to increase the contact between the reagents and catalyst, mimicking homogeneous catalysts while presenting the advantages of heterogeneous catalysis such as easy separation from the reaction mixture, and recyclability. Lewis acid supported on magnetite, constitute a very important synthetic tool for the multi-component approaches, e.g. Biginelli reaction. This transformation still attracts researchers attention because 3,4-dihydropyrimidin- 2(1H)-ones obtained from this multicomponent reaction showed a wide range of biological activities. Attempting to disclose further developments on sustainable protocols, heterogeneous catalysis and nanomaterials, herein, we report the multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones using a new, efficient, recyclable and reusable ferrite-Nb2O5 nanocatalyst.