Abstract:

Natural products play an important role in drug development, particularly in anticancer, antibiotics and antiparasitics drugs. [2,4’] or [2,5’] Bis-1,3- oxa/thia-aza scaffolds are present in numerous structures of marine natural products with interesting biological actvities. As examples, we cited Bengazoles, Laucamides and Largazole. As part of our search for compounds as candidates for anticancer or antiparasitic drugs employing molecular simplification, we are interested in an efficient methodology to synthesize bis-1,3- oxa/thiaaza like bis-thiazole (1, figure 1) and bisoxazoles or oxazol-thiazole (2, figure 1).