Towards efficient methods to construct bis-oxa/thiazoles

Towards efficient methods to construct bis-oxa/thiazoles

Landeira, Lucía; Parpal, Florencia; Manta, Eduardo; Serra, Gloria; Scarone, Laura

Abstract:

Natural products play an important role in drug development, particularly in anticancer, antibiotics and antiparasitics drugs. [2,4’] or [2,5’] Bis-1,3- oxa/thia-aza scaffolds are present in numerous structures of marine natural products with interesting biological actvities. As examples, we cited Bengazoles, Laucamides and Largazole. As part of our search for compounds as candidates for anticancer or antiparasitic drugs employing molecular simplification, we are interested in an efficient methodology to synthesize bis-1,3- oxa/thiaaza like bis-thiazole (1, figure 1) and bisoxazoles or oxazol-thiazole (2, figure 1).

Natural products play an important role in drug development, particularly in anticancer, antibiotics and antiparasitics drugs. [2,4’] or [2,5’] Bis-1,3- oxa/thia-aza scaffolds are present in numerous structures of marine natural products with interesting biological actvities. As examples, we cited Bengazoles, Laucamides and Largazole. As part of our search for compounds as candidates for anticancer or antiparasitic drugs employing molecular simplification, we are interested in an efficient methodology to synthesize bis-1,3- oxa/thiaaza like bis-thiazole (1, figure 1) and bisoxazoles or oxazol-thiazole (2, figure 1).

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0082-1

Referências bibliográficas

• [1] 1 Newman, D. J.; Cragg, G. M. J. Nat. Prod. 2007, 70, 461.
• [2] 2 Jin, Z. Nat. Prod. Rep. 2006, 23, 464.
• [3] 3 Scarone, L.; Fajardo, J.; Saldaña, J.; Domínguez, L.; Espósito, P.; Dematteis, S.; Wipf, P.; Manta, E.; Serra, G. Lett. Drug, Des. And Disc. 2009, 6, 413 and references cited there.
• [4] 4 Kuehne, M.E.; Shannon, P.J. J. Org. Chem. 1977, 42, 2082.
• [5] 5 Wipf, P.; Fletcher, J.M.; Scarone, L. Tetrahedron Lett 2005, 46, 5463.

Como citar:

Landeira, Lucía; Parpal, Florencia; Manta, Eduardo; Serra, Gloria; Scarone, Laura; "Towards efficient methods to construct bis-oxa/thiazoles", p-82-82. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0082-1