Total synthesis of targretin via palladium catalyzed crosscoupling reaction of a vinyl organozinc intermediate

Total synthesis of targretin via palladium catalyzed crosscoupling reaction of a vinyl organozinc intermediate

Jr., Palimécio G. Guerrero; Oliveira, Paulo R. de; Baroni, Adriano C. M.; Marques, Francisco A.; Hurtado, Gabriela R.; Dabdoub, Miguel J.

Abstract:

In the last two decades, retinoids as isotretinoin, etretinate and acitretin have been utilized in treatment of primary cutaneous T-cell lymphoma (CLTC) showing modest response in rats. However, the bexarotene (targretin®) 1 emerged as a potent and highly selective ligand for the retinoid X receptors (RXRs) applied in human patients to combat the CLTC, which have become a serious public health problem.

In the last two decades, retinoids as isotretinoin, etretinate and acitretin have been utilized in treatment of primary cutaneous T-cell lymphoma (CLTC) showing modest response in rats. However, the bexarotene (targretin®) 1 emerged as a potent and highly selective ligand for the retinoid X receptors (RXRs) applied in human patients to combat the CLTC, which have become a serious public health problem.

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DOI: 10.5151/chempro-14bmos-R0324-1

Referências bibliográficas

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Como citar:

Jr., Palimécio G. Guerrero; Oliveira, Paulo R. de; Baroni, Adriano C. M.; Marques, Francisco A.; Hurtado, Gabriela R.; Dabdoub, Miguel J.; "Total synthesis of targretin via palladium catalyzed crosscoupling reaction of a vinyl organozinc intermediate", p-324-324. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0324-1