Abstract:

Natural compounds of the 5,6-dihydropyranone family, isolated from the genus Cryptocarya (Laureacae), have attracted scientific interest due to their biological activities. Among these compounds, we highlight Cryptomoscatone D1 and D2, isolated from C. mandiocanna, for which a definitive proof of structure is still lacking. In this work, we describe our synthetic efforts toward compounds 1 and 2 in order to contribute to the elucidation of the stereochemistry of Criptomoscatones D1 and D2 (Figure 1).