Synthesis of Triazoles with Potential Antileishmanial Activity by Click Chemistry

Synthesis of Triazoles with Potential Antileishmanial Activity by Click Chemistry

Lima, Cíntia Maria Carneiro Franco; Victor., Maurício Moraes

Abstract:

Click Chemistry is an organic synthesis procedure, which follows the principles of green chemistry, being introduced by Sharpless in 2001. The most prominent chemical reaction using this procedure is the Cu(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition (CuAAC), leading to 1,2,3 triazoles. From this context, our approach aims to synthesize substances with potential antileishmanial activity similar as presented by Silva, using Click Chemistry but with innovation as the insertion of the triazole unit is presented below:

Click Chemistry is an organic synthesis procedure, which follows the principles of green chemistry, being introduced by Sharpless in 2001. The most prominent chemical reaction using this procedure is the Cu(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition (CuAAC), leading to 1,2,3 triazoles. From this context, our approach aims to synthesize substances with potential antileishmanial activity similar as presented by Silva, using Click Chemistry but with innovation as the insertion of the triazole unit is presented below:

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0321-1

Referências bibliográficas

• [1] 1 SHARPLESS, K.B; et al. Angew. Chem. 2001, 40, 2004-2021.
• [2] 2 KAPPE, C.O; van der EYCKEN, E. Chem. Soc. Rev. 2009, 39,1280-1290.
• [3] 3 SILVA, A.D; et al. Chem. Biol. Drug Des. 2010, 75, 233-235.
• [4] 4 NIERENGARTEN, J.F; et al. Tetrahedron Lett. 2008, 49, 4063-4066.

Como citar:

Lima, Cíntia Maria Carneiro Franco; Victor., Maurício Moraes; "Synthesis of Triazoles with Potential Antileishmanial Activity by Click Chemistry", p-321-321. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0321-1