Synthesis of squaraine dyes with potential application in protein detection by fluorescence spectroscopy

Synthesis of squaraine dyes with potential application in protein detection by fluorescence spectroscopy

Pisoni, Diego S.; Abreu, Marluza P. de; Petzhold, Cesar L.; Rodembusch, Fabiano S.; Campo, Leandra F.

Abstract:

Squaraines are interesting organic molecules due to the strong absorption in the visible region (e ~105 M-1•cm-1), intense fluorescence emission and good photoconductivity presented in these dyes. These features make them useful in a variety of applications in the area of imaging, nonlinear optics, photodynamic therapy and photovoltaic cells. Furthermore, squaraine dyes are suitable for fluorescence detection of proteins at longwavelength excitation and labels in biological assays due their unique photochemical and photophysical properties namely light absorption in the visible red and near-infrared regions. This work describes the synthesis of squaraine dyes prepared by the condensation of heteroaromatic compounds with a dialkyl ester derived from squaric acid in a one-step reaction.

Squaraines are interesting organic molecules due to the strong absorption in the visible region (e ~105 M-1•cm-1), intense fluorescence emission and good photoconductivity presented in these dyes. These features make them useful in a variety of applications in the area of imaging, nonlinear optics, photodynamic therapy and photovoltaic cells. Furthermore, squaraine dyes are suitable for fluorescence detection of proteins at longwavelength excitation and labels in biological assays due their unique photochemical and photophysical properties namely light absorption in the visible red and near-infrared regions. This work describes the synthesis of squaraine dyes prepared by the condensation of heteroaromatic compounds with a dialkyl ester derived from squaric acid in a one-step reaction.

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DOI: 10.5151/chempro-14bmos-R0159-1

Referências bibliográficas

• [1] 1 Volkova, K.D. et al. Dyes Pigments, 2007, 72, 285.
• [2] 2 Fabian, J. Chem. Rev. 1992, 92, 1197.
• [3] 3 Welder F. et al. J. Chromatogr. B 2003, 793, 93.

Como citar:

Pisoni, Diego S.; Abreu, Marluza P. de; Petzhold, Cesar L.; Rodembusch, Fabiano S.; Campo, Leandra F.; "Synthesis of squaraine dyes with potential application in protein detection by fluorescence spectroscopy", p-159-159. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0159-1