Abstract:

Thiosemicarbazones and 1,3,4-thiadiazoles have been reported to exhibit a wide range of biological effects among which are antitumor, antiprotozoal, and antimicrobial activities. The majority of the active thiosemicarbazones present the simplest aryl or alkyl groups at the N–4 and the more diverse R1 and R2 groups on the carbon at the imine moiety. Recently, our group has synthesized new thiosemicarbazones endowed with a bisabolol group on N-4 position which showed relevant antitumor activity. Herein, we report new thiosemicarbazones bearing a R-(+)-limonene moiety at the N-4 that were synthesized using silica supported acid under solvent-free conditions. Also, the synthesis of its 1,3,4–thiadiazoles derivatives is described.