Synthesis of potencial inhibitors of HIV-1Nef.

Synthesis of potencial inhibitors of HIV-1Nef.

Salvador, Carlos Eduardo M.; Andrade, Carlos Kleber Z.

Abstract:

A decreasing of the expression of CD4 receiver in the surface of the infected cells by Nef is one of the most important events during the infection by HIV-1. The identification of Nef inhibitors is very important to the treatment of HIV infection. The development of new therapies and methods of synthesis of Nef antagonists is a new and highly specific therapeutic approach and aims at eliminating the side effects involved with the existing anti-retroviral cocktail. To achieve this goal, we propose to synthesize a series of inhibitors of degradation of CD4 by Nef beginning with molecular modeling studies of the Nef protein and its catalytic domains involved in this function. In this sense, compound 1 seems to be one of the most promising (Figure 1).

A decreasing of the expression of CD4 receiver in the surface of the infected cells by Nef is one of the most important events during the infection by HIV-1. The identification of Nef inhibitors is very important to the treatment of HIV infection. The development of new therapies and methods of synthesis of Nef antagonists is a new and highly specific therapeutic approach and aims at eliminating the side effects involved with the existing anti-retroviral cocktail. To achieve this goal, we propose to synthesize a series of inhibitors of degradation of CD4 by Nef beginning with molecular modeling studies of the Nef protein and its catalytic domains involved in this function. In this sense, compound 1 seems to be one of the most promising (Figure 1).

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0310-1

Referências bibliográficas

• [1] 1 Arganaraz, E. R.; J. Biol. Chem. 2003, 36, 33912
• [2] 2 Salvador, C. E. M., Andrade, C. K. Z., Martins, J. B. L, 33a Reunião Anual da SBQ, 2010,
• [3] 3 Ulrich, M. S.; Buzko, O.; Shah, K.; Shokat, M. K.;Tetrahedron 2000, 56, 9495.

Como citar:

Salvador, Carlos Eduardo M.; Andrade, Carlos Kleber Z.; "Synthesis of potencial inhibitors of HIV-1Nef.", p-310-310. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0310-1