Synthesis of Novel Goniothalamin Analogs

Synthesis of Novel Goniothalamin Analogs

Barcelos, Rosimeire C.; Pilli, Ronaldo A.

Abstract:

The styryl lactone goniothalamin (1) is a secondary metabolite distributed among the plants of the genus Goniothalamus which has cytotoxic and antiproliferative properties. Given the interest of our research group to pursue studies of the biological activity of compounds based on its structure, we proposed the synthesis of hydrophilic analogs (2a-c). Moreover, the incorporation of fluorine into molecules has become a common tool in medicinal chemistry for improving the pharmacological profile of bioactive compounds. Thus, we proposed the synthesis of compounds (2d-e) containing the trifluoromethyl groups.

The styryl lactone goniothalamin (1) is a secondary metabolite distributed among the plants of the genus Goniothalamus which has cytotoxic and antiproliferative properties. Given the interest of our research group to pursue studies of the biological activity of compounds based on its structure, we proposed the synthesis of hydrophilic analogs (2a-c). Moreover, the incorporation of fluorine into molecules has become a common tool in medicinal chemistry for improving the pharmacological profile of bioactive compounds. Thus, we proposed the synthesis of compounds (2d-e) containing the trifluoromethyl groups.

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DOI: 10.5151/chempro-14bmos-R0327-1

Referências bibliográficas

• [1] 1Vendramini-Costa, D. B.; de Castro, I. B. D.; Ruiz, A. L. T. G.; Marquissolo, C.; Pilli, R. A.; de Carvalho, J. E. Bioorg. Med. Chem. 2010, 18 , 6742. 2de Fátima, A.; Zambuzzi, W. F.; Modolo, L. V.; Tarsitano, C. A. B.; Gadelha, F. R.; Hyslop, S.; de Carvalho, J. E.; Salgado, I.; Ferreira, C. V.; Pilli, R. A. Chem. Biol. Interact. 2008, 176, 143. 3Zhang, S.; Zhang, Y.; Ji, Y.; Li, H.; Wang, W. Chem. Commun. 2009, 4886. 4Hao, L.; Yafei, L.; Shilei, Z.; ChenGuang, Y.; Wei, W. Science China Chemistry. 2010, 53, 135. 5Dumitrescu, L.; Huong, D. T. M.; Hung, N. V.; Crousse, B. European Journal of Medicinal Chemistry. 2010, 45, 3213.

Como citar:

Barcelos, Rosimeire C.; Pilli, Ronaldo A.; "Synthesis of Novel Goniothalamin Analogs", p-327-327. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0327-1