Synthesis of new trichloro(fluoro)methylated biheterocycles

Synthesis of new trichloro(fluoro)methylated biheterocycles

Souto, Alynne A.; Flores, Alex F. C.; Malavolta, Juliana L.; Doneda, Morgana

Abstract:

Among the chemical compounds used in the pharmaceutical and agrochemicals industry, most of them have a heterocyclic ring. Among these, pyrazoles and pyrimidines, which have large importance in the field of medicinal chemistry, stand out being used as anti-inflammatory, antibiotics, analgesics, antibacterial, antineoplastic, among other. Biheterocycles have two heterocyclic rings connected by an alkyl group, carbonyl derivatives or directly between themselves. Their importance in the chemical industry and pharmaceutical has already been reported, mainly being used as hypoglycemic agents. Thus, the objectives of this work are the synthesis and reactivity study of hidrazides, pyrimidines and pyrazoles synthesized in our laboratories.

Among the chemical compounds used in the pharmaceutical and agrochemicals industry, most of them have a heterocyclic ring. Among these, pyrazoles and pyrimidines, which have large importance in the field of medicinal chemistry, stand out being used as anti-inflammatory, antibiotics, analgesics, antibacterial, antineoplastic, among other. Biheterocycles have two heterocyclic rings connected by an alkyl group, carbonyl derivatives or directly between themselves. Their importance in the chemical industry and pharmaceutical has already been reported, mainly being used as hypoglycemic agents. Thus, the objectives of this work are the synthesis and reactivity study of hidrazides, pyrimidines and pyrazoles synthesized in our laboratories.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0108-1

Referências bibliográficas

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Como citar:

Souto, Alynne A.; Flores, Alex F. C.; Malavolta, Juliana L.; Doneda, Morgana; "Synthesis of new trichloro(fluoro)methylated biheterocycles", p-108-108. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0108-1