Synthesis of New Arylsulfonylhydrazide-1,2,3-Triazole Derivatives from Diazocarbonyl Compound

Synthesis of New Arylsulfonylhydrazide-1,2,3-Triazole Derivatives from Diazocarbonyl Compound

Campos, Vinícius Rangel; Dias, Flaviana Rodrigues Filteman; Ferreira, Vitor Francisco; Souza, Maria Cecília Bastos Vieira de; Cunha, Anna Claudia

Abstract:

Recently, we described the synthesis and pharmacological evaluation of 1,2,3-triazole derivatives. In this study, it was found that the compounds 1-[(5´´-methyl-1´´-(4´´´- fluorophenylamino)-1H-1,2,3-triazol-4´´-yl)carbonyl]- 2-(4´methylphenylsulfonyl)hydrazine and 1-[(5´- methyl-1´-(2´´,5´´-dichlorophenylamino)-1H-1,2,3- triazol-4´-yl)carbonyl]-2-(phenylsulfonyl)hydrazine exhibited a significant effect against HSV-1 replication in cell culture. In an effort to optimize the antiviral activity of these structurally triazole compounds, we now described the synthesis of a new family of triazol derivates 1a-f.

Recently, we described the synthesis and pharmacological evaluation of 1,2,3-triazole derivatives. In this study, it was found that the compounds 1-[(5´´-methyl-1´´-(4´´´- fluorophenylamino)-1H-1,2,3-triazol-4´´-yl)carbonyl]- 2-(4´methylphenylsulfonyl)hydrazine and 1-[(5´- methyl-1´-(2´´,5´´-dichlorophenylamino)-1H-1,2,3- triazol-4´-yl)carbonyl]-2-(phenylsulfonyl)hydrazine exhibited a significant effect against HSV-1 replication in cell culture. In an effort to optimize the antiviral activity of these structurally triazole compounds, we now described the synthesis of a new family of triazol derivates 1a-f.

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DOI: 10.5151/chempro-14bmos-R0253-1

Referências bibliográficas

• [1] 1 Jordão, A. K.; Ferreira, V. F.; Souza, T. M. L.; Faria, G. G. S.; Machado, V.; Abrantes, J. L.; Souza, M. C. B. V.; Cunha, A. C. Bioorg. Med. Chem. 2011, 19, 1860.
• [2] 2 Campos, V. R.; Abreu, P. A.; Castro, H. C.; Rodrigues, C. R.; Jordão, A. K.; Ferreira, V. F.; Souza, M. C. B. V.; Santos, F. C.; Moura, L. A.; Domingos, T. S.; Sanchez, E. F. Fuly, A. L.; Cunha, A. C. Bioorg. Med. Chem. 2009, 17, 7429.
• [3] 3 Jordão, A. K.; Afonso, P. P.; Ferreira, V. F.; De Souza, M. C. B. V.; Almeida, M. C. B.; Beltrame, C. O.; Paiva, D. P.; Wardell, S. M. S. V.; Wardell, J. L.; Tiekink, E. R. T.; Damaso, C. R.; Cunha, A. C. Eur. J. Med. Chem. 2009, 44, 3777.

Como citar:

Campos, Vinícius Rangel; Dias, Flaviana Rodrigues Filteman; Ferreira, Vitor Francisco; Souza, Maria Cecília Bastos Vieira de; Cunha, Anna Claudia; "Synthesis of New Arylsulfonylhydrazide-1,2,3-Triazole Derivatives from Diazocarbonyl Compound", p-253-253. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0253-1