Synthesis of New 1,2,3-triazole-1,4-naphthoquinones

Synthesis of New 1,2,3-triazole-1,4-naphthoquinones

Nascimento, Wilson S.; Camara, Celso Amorim; Oliveira, Ronaldo N. de

Abstract:

The development of new molecular libraries for biological screening has gained impact among synthetic chemists. The N-heterocycle, namely 1,2,3-triazole, have received considerable attention in the search for new drugs in pharmacology. Hence, many efforts have been made in the optimization of their preparation methods. One example is the 1,3-dipolar cycloaddition reaction between an azide and a terminal alkyne to obtain this triazole, using a copper-based catalyst. Substituted naphthoquinones are reported to display important biological activity. For this reason, we turned our attention to the investigation of N-triazole linked with 1,4-naphthaquinone, in the course of a project involving the synthesis and biological evaluation of a series of new heterocyclic derivatives.

The development of new molecular libraries for biological screening has gained impact among synthetic chemists. The N-heterocycle, namely 1,2,3-triazole, have received considerable attention in the search for new drugs in pharmacology. Hence, many efforts have been made in the optimization of their preparation methods. One example is the 1,3-dipolar cycloaddition reaction between an azide and a terminal alkyne to obtain this triazole, using a copper-based catalyst. Substituted naphthoquinones are reported to display important biological activity. For this reason, we turned our attention to the investigation of N-triazole linked with 1,4-naphthaquinone, in the course of a project involving the synthesis and biological evaluation of a series of new heterocyclic derivatives.

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DOI: 10.5151/chempro-14bmos-R0330-2

Referências bibliográficas

• [1] 1 Meldal, M.; Tornøe, C. W. Chem. Rev. 2008, 108, 2952.
• [2] 2 Cunha, A. S.; Lima, E. L. S.; Pinto, A. C.; Esteves-Souza, A.; Echevarria, A.; Camara, C. A.;Vargas, M. D.; Torres, S. J. J. Braz. Chem. Soc. 2006, 17, 439.
• [3] 3 Barbosa, F.C.G.; de Oliveira, R.N. J. Braz. Chem. Soc. 2011, 22, 592.

Como citar:

Nascimento, Wilson S.; Camara, Celso Amorim; Oliveira, Ronaldo N. de; "Synthesis of New 1,2,3-triazole-1,4-naphthoquinones", p-330-330. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0330-2