Synthesis of Hidroxamic acid and Proline derivatives of Diselenide as Mimetics Enzyme to GPx.

Synthesis of Hidroxamic acid and Proline derivatives of Diselenide as Mimetics Enzyme to GPx.

Liz, Daiane Gobbatto de; silveira, Gustavo P.; Braga, Antonio Luiz

Abstract:

Seleno amino acids and peptides are promising agents that mimic the enzyme glutathione peroxidase (GPx). Recently, our research group prepared a library at new selenide and diselenide derivatives of amino acids. They were able to promote the catalytic reduction of H2O2 to water at the expense of oxidation of thiols at the speed higher than the already known mimetic of GPx, diphenyl diselenide Numerous natural products contains the pyrrolidine ring in their structure, showing significant biological activities and used as therapeutic agent. Similary hydroxamic acids got recent focus in chemistry due its biological its aspect. The present work shows the synthesis of new diselenide derivatives of the proline and hydroxamic acids as potential mimetics GPx.

Seleno amino acids and peptides are promising agents that mimic the enzyme glutathione peroxidase (GPx). Recently, our research group prepared a library at new selenide and diselenide derivatives of amino acids. They were able to promote the catalytic reduction of H2O2 to water at the expense of oxidation of thiols at the speed higher than the already known mimetic of GPx, diphenyl diselenide Numerous natural products contains the pyrrolidine ring in their structure, showing significant biological activities and used as therapeutic agent. Similary hydroxamic acids got recent focus in chemistry due its biological its aspect. The present work shows the synthesis of new diselenide derivatives of the proline and hydroxamic acids as potential mimetics GPx.

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DOI: 10.5151/chempro-14bmos-R0359-2

Referências bibliográficas

• [1] 1 Yoshida, S.; Kumakura, F. et al. Angewandte. 2010, 50,1-5
• [2] 2 Kitajima, H.; Sakashita, H. et al. Preparation of proline derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors and use thereof as drugs. PCT Int. Appl. (2002), WO 2002014271
• [3] 3 Becker, D. P.; Vilamil, C. I. et al. J. Med. Chem. 2005, 48, 6713.

Como citar:

Liz, Daiane Gobbatto de; silveira, Gustavo P.; Braga, Antonio Luiz; "Synthesis of Hidroxamic acid and Proline derivatives of Diselenide as Mimetics Enzyme to GPx.", p-359-359. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0359-2