Synthesis of fluorescent 2,1,3-benzothiadiazole-triazole-linked glycoconjugates

Synthesis of fluorescent 2,1,3-benzothiadiazole-triazole-linked glycoconjugates

Moro, Angélica V.; Ferreira, Patrícia C.; Migowski, Pedro; Lüdtke, Diogo S.; Dupont, Jairton

Abstract:

Fluorescent 2,1,3-benzothiadiazol (BTD) derivatives have been described as useful dyes. In this context, the synthesis of carbohydrate functionalized BTDs is an interesting strategy for glycoconjugation and also a promising approach for chiral fluorescent molecules with many potential applications as chemosensors. Herein we report our results on the synthesis of BTD-triazol-linked glycoconjugates through a Cu(I)-catalyzed alkyne-azide cycloaddition.

Fluorescent 2,1,3-benzothiadiazol (BTD) derivatives have been described as useful dyes. In this context, the synthesis of carbohydrate functionalized BTDs is an interesting strategy for glycoconjugation and also a promising approach for chiral fluorescent molecules with many potential applications as chemosensors. Herein we report our results on the synthesis of BTD-triazol-linked glycoconjugates through a Cu(I)-catalyzed alkyne-azide cycloaddition.

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DOI: 10.5151/chempro-14bmos-R0277-1

Referências bibliográficas

• [1] 1 Neto, B. A. D.; Lapis, A. A. M.; Mancilha, F. S.; Batista Jr, E. L.; Netz, P. A.; Basso, L. A.; Santos, D. S.; Dupont, J. Mol. BioSyst. 2010, 6, 967.
• [2] 2 Pu, L. Chem. Rev. 2004, 106, 1687
• [3] 3 Wouters, A. D.; Trossini, G. H. G.; Stefani, H. A.; Lüdtke, D. S. Eur. J. Org. Chem. 2010, 2351.

Como citar:

Moro, Angélica V.; Ferreira, Patrícia C.; Migowski, Pedro; Lüdtke, Diogo S.; Dupont, Jairton; "Synthesis of fluorescent 2,1,3-benzothiadiazole-triazole-linked glycoconjugates", p-277-277. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0277-1