Abstract:

In recent years, the synthesis of many heterocycles has attracted the interest of the scientific community due to the wide applicability of these compounds in various fields of modern chemistry, and they have a huge variety and structural complexity. Among these systems stand out heterocyclic pyrimidines and their derivatives due to their biological importance and biological activities, such as antibiotics, antiviral, antitumor, anti-inflammatory, among others. This is because the pyrimidines are present in living organisms and many of them are part of nucleic acids (DNA and RNA), and therefore, are essential in protein biosynthesis. Moreover, it is observed that the bioactivity of these molecules can be changed or disabled by simply changing the position or the type of substituent in the heterocycle. In this context, the synthesis of pyrimidines with an unprecedented variety of substituents and positions emerges as an important tool for the production of promising drugs for various diseases.