Synthesis of Bacillamide C analogues

Synthesis of Bacillamide C analogues

Martínez, Verónica R.; Serra, Gloria; Davyt, Danilo

Abstract:

The Bacillamide A (1) recently isolated from the marine bacterium Bacillus sp. SY-1, is a compound with algaecide activity against the harmful dinoflagellate Cochlodinium polykrikoides. The bacillamide C (2) isolated from a Bahamian hypersaline microbial mat, has not been tested for algicidal activity due to a lack of sufficient material. Different synthesis of this compound were described in literature. In this work we prepare the Bacillamide 2, by eight steps starting from L-alanine.

The Bacillamide A (1) recently isolated from the marine bacterium Bacillus sp. SY-1, is a compound with algaecide activity against the harmful dinoflagellate Cochlodinium polykrikoides. The bacillamide C (2) isolated from a Bahamian hypersaline microbial mat, has not been tested for algicidal activity due to a lack of sufficient material. Different synthesis of this compound were described in literature. In this work we prepare the Bacillamide 2, by eight steps starting from L-alanine.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0066-1

Referências bibliográficas

• [1] 1 Socha, A. M.; Long, R. A. e Rowley, D. C. J. Nat. Prod. 2007, 70, 1793.
• [2] 2 Li, D.; Yang H. S.; Cui Q.; Mao S. J. e Xu X. H. Chin. Chem. Lett. 2009, 20, 1195
• [3] 3 Gaumont, A.; Gulea,M.; Levillain, J. Chem. Rev. 2009, 109, 1371– 1401
• [4] 4 Seiser, T.; Kamena, F.E., Cramer, N. Angew. Chem. Int. Ed. 2008, 47, 6483
• [5] 5 Phillips, A. J.; Uto, Y.; Wipf, P; Reno, M. e Williams, D. R. Org. Lett., 2000, 2, 1165

Como citar:

Martínez, Verónica R.; Serra, Gloria; Davyt, Danilo; "Synthesis of Bacillamide C analogues", p-66-66. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0066-1