Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

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Synthesis of Azapterocarpan Analogues by Intramolecular 1,3-dipolar Cycloaddition

Barcellos, Júlio C. F. ; G.Dias, Ayres ; R.Costa, Paulo R. ;

Abstract:

As part of a program directed at the discovery of new anticancer and antiparasitic drugs, our laboratory synthesized very promising new azapterocarpan analogues type 1, through a palladium catalyzed aza-arylation reaction (Figure 1). Now we are concentrating our efforts in the synthesis of analogues of 1, type 2-4, through intramolecular 1,3 dipolar cycloaddition, (1,3-IDC).

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Palavras-chave: aza pterocarpan, Intramolecular 1, 3-dipolar cycloaddition, antiparasitic drugs, anticancer,

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DOI: 10.5151/chempro-14bmos-R0090-2

Referências bibliográficas
  • [1] 1 Djenne, B.C. PhD Thesis, NPPN-UFRJ, December 2010, Costa, P.R.R. et all J. Braz. Chem. Soc. 2009, 20,1916.
  • [2] 2 Kurth, M.J. et all, J. Org. Chem. Soc. 1998, 63, 3081
  • [3] 3 Grigg, R. et all, Tetrahedron. 1995, 51, 27
Como citar:

Barcellos, Júlio C. F.; G.Dias, Ayres; R.Costa, Paulo R.; "Synthesis of Azapterocarpan Analogues by Intramolecular 1,3-dipolar Cycloaddition", p. 90 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0090-2

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