Synthesis of Azapterocarpan Analogues by Intramolecular 1,3-dipolar Cycloaddition

Synthesis of Azapterocarpan Analogues by Intramolecular 1,3-dipolar Cycloaddition

Barcellos, J.C.F.; Dias, A.G.; Costa, P.R.R.

Abstract:

As part of a program directed at the discovery of new anticancer and antiparasitic drugs, our laboratory synthesized very promising new azapterocarpan analogues type 1, through a palladium catalyzed aza-arylation reaction (Figure 1). Now we are concentrating our efforts in the synthesis of analogues of 1, type 2-4, all obtained by intramolecular 1,3 dipolar cycloaddition, (1,3-IDC).

As part of a program directed at the discovery of new anticancer and antiparasitic drugs, our laboratory synthesized very promising new azapterocarpan analogues type 1, through a palladium catalyzed aza-arylation reaction (Figure 1). Now we are concentrating our efforts in the synthesis of analogues of 1, type 2-4, all obtained by intramolecular 1,3 dipolar cycloaddition, (1,3-IDC).

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0090-1

Referências bibliográficas

• [1] 1 Djenne, B.C. PhD Thesis, NPPN-UFRJ, December 2010, Costa, P.R.R. et all J. Braz. Chem. Soc. 2009, 20,1916.
• [2] 2 Kurth, M.J. et all, J. Org. Chem. Soc. 1998, 63, 3081
• [3] 3 Grigg, R. et all, Tetrahedron. 1995, 51, 273.

Como citar:

Barcellos, J.C.F.; Dias, A.G.; Costa, P.R.R.; "Synthesis of Azapterocarpan Analogues by Intramolecular 1,3-dipolar Cycloaddition", p-90-90. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0090-1