Synthesis of 3,4-Dihydro- -Pyrone Analogues of Goniothalamin

Synthesis of 3,4-Dihydro- -Pyrone Analogues of Goniothalamin

Pastre, Julio Cezar; Pilli, Ronaldo Aloise

Abstract:

In an ongoing program to identify new candidates for cancer treatment, goniothalamin 1 (Figure 1) was recognized as a good lead compound with significant cytotoxicity against a variety of cancer cell lines, including cervical, kidney, prostate, breast carcinoma and leukemia. In an attempt to develop new analogues with higher activity and selectivity, we decided to prepare 3,4-dihydro- -pyrone analogues of goniothalamin.

In an ongoing program to identify new candidates for cancer treatment, goniothalamin 1 (Figure 1) was recognized as a good lead compound with significant cytotoxicity against a variety of cancer cell lines, including cervical, kidney, prostate, breast carcinoma and leukemia. In an attempt to develop new analogues with higher activity and selectivity, we decided to prepare 3,4-dihydro- -pyrone analogues of goniothalamin.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0278-1

Referências bibliográficas

• [1] 1 (a) de Fátima et al. Biorg. Med. Chem. 2006, 14, 622. (b) de Fátima et al. Chem. Biol. Interact. 2008, 176, 143. (c) Vendramini-Costa, D. B. et al. Biorg. Med. Chem. 2010, 18, 6742.
• [2] 2 Huang, Y.; Rawal, V. H. Org. Lett. 2000, 2, 3321.
• [3] 3 Kasaplar. P. et al. Biorg. Med. Chem. 2009, 17, 311.

Como citar:

Pastre, Julio Cezar; Pilli, Ronaldo Aloise; "Synthesis of 3,4-Dihydro- -Pyrone Analogues of Goniothalamin", p-278-278. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0278-1