Synthesis of 1,3,4-oxadiazoles derivatives from -amino acids and acyl hydrazides using microwave irradiation

Synthesis of 1,3,4-oxadiazoles derivatives from -amino acids and acyl hydrazides using microwave irradiation

Martins, Bruna Simões; Heck, Elisiane Frantz; Bender, Caroline Raquel; Filho, Wolmar A. Severo; Braga, Antonio L.; Rodrigues, Oscar E. Dorneles; Dornelles, Luciano

Abstract:

The 1,3,4-oxadiazoles constitute an important family of heterocyclic compounds as they have attracted significant interest in medicinal chemistry, pesticide chemistry and polymer science. These compounds derivatives have been found to exhibit diverse biological activities such as analgesic, antiinflammatory, antimicrobial, anti-HIV and other biological properties. Consequently, the synthesis of compounds containing this heterocycle core has attracted considerable attention and a wide variety of methods have been used for its assembly. By far the most common synthetically protocol involves the dehydrative cyclization of diacylhydrazides, usually with strongly acidic reagents such as SOCl2, P2O5, POCl3 and H2SO4.

The 1,3,4-oxadiazoles constitute an important family of heterocyclic compounds as they have attracted significant interest in medicinal chemistry, pesticide chemistry and polymer science. These compounds derivatives have been found to exhibit diverse biological activities such as analgesic, antiinflammatory, antimicrobial, anti-HIV and other biological properties. Consequently, the synthesis of compounds containing this heterocycle core has attracted considerable attention and a wide variety of methods have been used for its assembly. By far the most common synthetically protocol involves the dehydrative cyclization of diacylhydrazides, usually with strongly acidic reagents such as SOCl2, P2O5, POCl3 and H2SO4.

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DOI: 10.5151/chempro-14bmos-R0364-1

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Como citar:

Martins, Bruna Simões; Heck, Elisiane Frantz; Bender, Caroline Raquel; Filho, Wolmar A. Severo; Braga, Antonio L.; Rodrigues, Oscar E. Dorneles; Dornelles, Luciano; "Synthesis of 1,3,4-oxadiazoles derivatives from -amino acids and acyl hydrazides using microwave irradiation", p-364-364. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0364-1