Synthesis and properties of polymer water-soluble films with antitumoral, antiseptic and nitric monoxide (NO) donating activities

Synthesis and properties of polymer water-soluble films with antitumoral, antiseptic and nitric monoxide (NO) donating activities

Sanina, N.A.; Shmatko, N. Yu

Abstract:

The search for new approaches to the development of effective and non-toxic materials-prodrugs based on metal coordination compounds has been performed intensely in leading laboratories world-wide. Synthetic models of nitrosyl intermediates forming in the cells upon the interaction of endogenous nitric monoxide (NO) with active sites of ferredoxines are of great scientific interest. It is known that nitrosyl iron complexes ae intermediates in the decomposition of proteins and formation of S-nitrosothiol, which are catalyzed by the iron, and are reservoirs and transporters of No in vivo. The objective of this work is to develop procedures for synthesis of water-soluble polymer composites with iron-sulfur complexes as NO donors with antseptic and antitumoral activities and to study their properties in order to use them as NO donors materials in the in the treatment of socially significant diseases, viz. in the NO-therapy of oncological and infectious diseases. The high homogeneity wit fine distribution of nitrosyl complexes into volume of polymer should be provided.

The search for new approaches to the development of effective and non-toxic materials-prodrugs based on metal coordination compounds has been performed intensely in leading laboratories world-wide. Synthetic models of nitrosyl intermediates forming in the cells upon the interaction of endogenous nitric monoxide (NO) with active sites of ferredoxines are of great scientific interest. It is known that nitrosyl iron complexes ae intermediates in the decomposition of proteins and formation of S-nitrosothiol, which are catalyzed by the iron, and are reservoirs and transporters of No in vivo. The objective of this work is to develop procedures for synthesis of water-soluble polymer composites with iron-sulfur complexes as NO donors with antseptic and antitumoral activities and to study their properties in order to use them as NO donors materials in the in the treatment of socially significant diseases, viz. in the NO-therapy of oncological and infectious diseases. The high homogeneity wit fine distribution of nitrosyl complexes into volume of polymer should be provided.

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Como citar:

Sanina, N.A.; Shmatko, N. Yu; "Synthesis and properties of polymer water-soluble films with antitumoral, antiseptic and nitric monoxide (NO) donating activities", p-92-92. In: Proceedings of the 13th International Symposium on Multiscale, Multifunctional and Functionally Graded Materials [=Blucher Material Science Proceedings, v.1, n.1]. São Paulo: Blucher, 2014.
ISSN 23589337, DOI