Synthesis and Citotoxicity Evaluation of 3-Cyano-2-aminocycloalkyl[ b]thiophene derivatives

Synthesis and Citotoxicity Evaluation of 3-Cyano-2-aminocycloalkyl[ b]thiophene derivatives

MOURA, R.O.; DE ARAÚJO, R.S.A.; RIBEIRO, F.F.; CRUZ, R.M.D.; DE OLIVEIRA, J.G.B.; DA-CRUZ, R.M.D.; MONTEIRO, M.B.; MENDONÇA JUNIOR, F.J.B.

Abstract:

The synthesis of new bioactive compounds requires preliminary testing to determine the toxicity and provide important indications of the feasibility of in vivo tests. The brine shrimp (Artemia salina) is a microcrustacean used as an animal model to determine the citotoxicity of synthetic compounds and natural products in lethality bioassays. This is a quickly and cheaply test with high correlation with other cytotoxicity bioassays. This study aims to synthesize and evaluate the citotoxicity of 2-amino- 3-cyano-cycloalkyl[b]thiophene derivatives which possessed significant antifungal activity in vitro, through the Artemia salina lethality bioassay.

The synthesis of new bioactive compounds requires preliminary testing to determine the toxicity and provide important indications of the feasibility of in vivo tests. The brine shrimp (Artemia salina) is a microcrustacean used as an animal model to determine the citotoxicity of synthetic compounds and natural products in lethality bioassays. This is a quickly and cheaply test with high correlation with other cytotoxicity bioassays. This study aims to synthesize and evaluate the citotoxicity of 2-amino- 3-cyano-cycloalkyl[b]thiophene derivatives which possessed significant antifungal activity in vitro, through the Artemia salina lethality bioassay.

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DOI: 10.5151/chempro-14bmos-R0288-2

Referências bibliográficas

• [1] 1 Gewald, K.; Schinke, E.; Bottcher, H. Chem Ber. 1966, 94.
• [2] 2 Meyer, B. N.; Ferrigni, N. R.; Putnam, L. B.; Jacobsen, L. B.; Nichols, D. E.; McLaughlin, J. L. Planta Medica. 1982, 45, 31.
• [3] 3 Finey, D.J. Probit analysis. 3rd ed. Cambridge University Press, Cambridge, 1971.

Como citar:

MOURA, R.O.; DE ARAÚJO, R.S.A.; RIBEIRO, F.F.; CRUZ, R.M.D.; DE OLIVEIRA, J.G.B.; DA-CRUZ, R.M.D.; MONTEIRO, M.B.; MENDONÇA JUNIOR, F.J.B.; "Synthesis and Citotoxicity Evaluation of 3-Cyano-2-aminocycloalkyl[ b]thiophene derivatives", p-288-288. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0288-2