Synthesis and antimicrobial evaluation of 4-aryl-4,5-dihydro- 1H-1,5-benzodiazepin-2-ol derivatives

Synthesis and antimicrobial evaluation of 4-aryl-4,5-dihydro- 1H-1,5-benzodiazepin-2-ol derivatives

Ochoa, Estael; Canaan, Claudia; Verdecia, Yamila; Peralta, Edna Dória; Calderón, Osmar; Ramos, Raúl; Seruto, Yeily; Neto, Aristóteles Góes; Alvarez, Heiddy Marquez; Lucchese, Angélica Maria

Abstract:

Benzodiazepines (BDZ) derivatives constituted the first pharmacological entity coined with the term privileged structure, due to their large number of therapeutic and pharmacological properties. Besides the well-known Nervous Central System related properties (ansiolytic, hypnotic and anticonvulsant, among others), they had been found also useful as antibiotic, antiviral (HIV-1), antitumor or cardiovascular drugs. In the other hand 1,5- benzodiazepine moiety had been much less studied than 1,4-benzodiazepines counterparts. In this work, it is reported the synthesis, characterization and antimicrobiological evaluation of different 4-aryl-4,5-dihydro-1H-1,5-benzodiazepin- 2-ol derivatives.

Benzodiazepines (BDZ) derivatives constituted the first pharmacological entity coined with the term privileged structure, due to their large number of therapeutic and pharmacological properties. Besides the well-known Nervous Central System related properties (ansiolytic, hypnotic and anticonvulsant, among others), they had been found also useful as antibiotic, antiviral (HIV-1), antitumor or cardiovascular drugs. In the other hand 1,5- benzodiazepine moiety had been much less studied than 1,4-benzodiazepines counterparts. In this work, it is reported the synthesis, characterization and antimicrobiological evaluation of different 4-aryl-4,5-dihydro-1H-1,5-benzodiazepin- 2-ol derivatives.

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DOI: 10.5151/chempro-14bmos-R0049-1

Referências bibliográficas

• [1] 1. Nicolaou K. C., Pfefferkorn J. A., Roecker A. J., Cao G.-Q., Barluenga S., Mitchell H. J., J. Am. Chem. Soc., 2000, 122, 9939.
• [2] 2. Horton D. A., Bourne G. T., Smythe M. L.., Chem. Rev., 2003, 103(3), 893

Como citar:

Ochoa, Estael; Canaan, Claudia; Verdecia, Yamila; Peralta, Edna Dória; Calderón, Osmar; Ramos, Raúl; Seruto, Yeily; Neto, Aristóteles Góes; Alvarez, Heiddy Marquez; Lucchese, Angélica Maria; "Synthesis and antimicrobial evaluation of 4-aryl-4,5-dihydro- 1H-1,5-benzodiazepin-2-ol derivatives", p-49-49. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0049-1