Studies Towards the Synthesis of Goniotrionin

Studies Towards the Synthesis of Goniotrionin

Ferreira, Marco Antonio Barbosa; Dias, Luiz Carlos

Abstract:

Annonaceous acetogenins are a class of natural polyketides which have promising anticancer, antiinfective, and pesticidal properties. Goniotrionin 1 is a potent antitumor agent which acts in NADH:ubiquinone oxirredutase. It was isolated in small amounts by McLaughlin et al. in 1998 from Annonaceae tree native to Thailand. To provide material for further biological studies as well as access to novel analogues, we initiated a study towards the synthesis of Goniotrionin.

Annonaceous acetogenins are a class of natural polyketides which have promising anticancer, antiinfective, and pesticidal properties. Goniotrionin 1 is a potent antitumor agent which acts in NADH:ubiquinone oxirredutase. It was isolated in small amounts by McLaughlin et al. in 1998 from Annonaceae tree native to Thailand. To provide material for further biological studies as well as access to novel analogues, we initiated a study towards the synthesis of Goniotrionin.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0088-1

Referências bibliográficas

• [1] 1 Alali, F. Q.; Rogers, L.; Zhang, Y; McLaughlin, J. L. Tetrahedron 1998, 54, 5833.
• [2] 2 Inoki, S.; Mukaiyama, T. Chem Lett. 1990, 67.
• [3] 3 Marshall, J. A.; Piettre, A.; Paige, M. A.; Valeriote, F. J. Org. Chem. 2003, 68, 1771.
• [4] 4 Müller, S.; Liepold, B.; Roth, G. J.; Bestmann, H. J. Synlett, 1996, 521.

Como citar:

Ferreira, Marco Antonio Barbosa; Dias, Luiz Carlos; "Studies Towards the Synthesis of Goniotrionin", p-88-88. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0088-1