Studies Towards new Ribavirin Nucleoside Analogs

Studies Towards new Ribavirin Nucleoside Analogs

Miranda, Leandro Soter de Mariz e; Souza, Rodrigo Octávio Mendonça Alves de; Uziel, Jacques; Lubin-Germain., Nadège

Abstract:

Hepatitis C is a viral infection that commits about 3-4 million people per year worldwide. Its treatment consists mainly in the administration of interferon a and Ribavirin. However the collateral effects associated with this treatment, specifically attributed to the Ribavirin, precludes the treatment in some patients, which make the search for new drugs a very important issue. The discovery of a high active Ribavirin analog denominated SR91, figure 1, towards inhibition of IMP-DH prompted us to further investigate and pursuit in the direction of synthesizing new derivatives guided by a in silico docking study. In these studies the structures 2 and 3, figure 2 emerged as potential candidates and their synthesis was studied. The methodology used was based on the indium mediated alkynylation of sugar acetates. The triazole ring was constructed through a micellar catalyzed Huisgen cycloaddition developed by Uziel and col.

Hepatitis C is a viral infection that commits about 3-4 million people per year worldwide. Its treatment consists mainly in the administration of interferon a and Ribavirin. However the collateral effects associated with this treatment, specifically attributed to the Ribavirin, precludes the treatment in some patients, which make the search for new drugs a very important issue. The discovery of a high active Ribavirin analog denominated SR91, figure 1, towards inhibition of IMP-DH prompted us to further investigate and pursuit in the direction of synthesizing new derivatives guided by a in silico docking study. In these studies the structures 2 and 3, figure 2 emerged as potential candidates and their synthesis was studied. The methodology used was based on the indium mediated alkynylation of sugar acetates. The triazole ring was constructed through a micellar catalyzed Huisgen cycloaddition developed by Uziel and col.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0137-1

Referências bibliográficas

• [1] Ramzi Ait Youcef, Mickael Dos Santos, Sandrine Roussel, Jean-Pierre Baltaze, Nadege Lubin-Germain and Jacques Uziel. . Org. Chem., 2009, 74 (11), pp 4318–4323

Como citar:

Miranda, Leandro Soter de Mariz e; Souza, Rodrigo Octávio Mendonça Alves de; Uziel, Jacques; Lubin-Germain., Nadège; "Studies Towards new Ribavirin Nucleoside Analogs", p-137-137. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0137-1