Abstract:

Hepatitis C is a viral infection that commits about 3-4 million people per year worldwide. Its treatment consists mainly in the administration of interferon a and Ribavirin. However the collateral effects associated with this treatment, specifically attributed to the Ribavirin, precludes the treatment in some patients, which make the search for new drugs a very important issue. The discovery of a high active Ribavirin analog denominated SR91, figure 1, towards inhibition of IMP-DH prompted us to further investigate and pursuit in the direction of synthesizing new derivatives guided by a in silico docking study. In these studies the structures 2 and 3, figure 2 emerged as potential candidates and their synthesis was studied. The methodology used was based on the indium mediated alkynylation of sugar acetates. The triazole ring was constructed through a micellar catalyzed Huisgen cycloaddition developed by Uziel and col.