Studies Toward the Total Synthesis of Combretastatin D4

Studies Toward the Total Synthesis of Combretastatin D4

Nascimento, Wilson S.; Martinez, Walter R.; Silva, Arisson T.; Paulino, Antônio A. S.; Menezes, Paulo H.; Oliveira, Roberta A.

Abstract:

Compounds isolated from Combretaceae are of great interest and include the bioactive stilbenes and the 17-membered macrocyclic lactones Combretastatins D2 and D4 (Figure 1). Different approaches for the synthesis of Combretastatin D2 have been described, but due to date no synthetic approaches as well as cytotoxicity studies have been reported for Combretastatin D4 (CA-D4). The interest in the design and synthesis of angiogenesis inhibitors prompted us to design a new, convergent route to this class of compounds with a view to further studies of biological properties of the natural product and its analogues.

Compounds isolated from Combretaceae are of great interest and include the bioactive stilbenes and the 17-membered macrocyclic lactones Combretastatins D2 and D4 (Figure 1). Different approaches for the synthesis of Combretastatin D2 have been described, but due to date no synthetic approaches as well as cytotoxicity studies have been reported for Combretastatin D4 (CA-D4). The interest in the design and synthesis of angiogenesis inhibitors prompted us to design a new, convergent route to this class of compounds with a view to further studies of biological properties of the natural product and its analogues.

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DOI: 10.5151/chempro-14bmos-R0330-1

Referências bibliográficas

• [1] 1 Cirla, A.; Mann, J. Nat. Prod. Rep., 2003, 20, 558–564.
• [2] 2Oliveira, R. A.; Molander G. A. Tetrahedron Lett. 2008, 49, 1266-1268.
• [3] 3 Quach, T. D.; Batey, R.A. Org. Lett. 2003, 5, 1381-1384.

Como citar:

Nascimento, Wilson S.; Martinez, Walter R.; Silva, Arisson T.; Paulino, Antônio A. S.; Menezes, Paulo H.; Oliveira, Roberta A.; "Studies Toward the Total Synthesis of Combretastatin D4", p-330-330. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0330-1