Studies toward the synthesis of the L-thyroxine hormone.

Studies toward the synthesis of the L-thyroxine hormone.

Gallo, Rafael D. C.; Frota, Carlise; Raminelli, Cristiano

Abstract:

L-Thyroxine (T4) (1) is a hormone produced by the thyroid gland. The thyroid gland uses iodine, from exogenous sources, to produce L-thyroxine (1), which acts as a precursor of 3,5,3’-triiodothyronine (T3). Individuals with low levels of T4 and T3 can suffer from hypothyroidism. Accordingly, L-thyroxine (1) has been indicated for the treatment of this type of endocrine disorder. Although since 1927 the production of the T4 hormone is carried out in laboratory, short synthetic routes involving mild reaction conditions to obtain this important substance are still of considerable interest. In this work we show our preliminary results toward the synthesis of L-thyroxine (1) employing a route that will use in two steps an efficient and selective diiodination reaction developed in our research group.

L-Thyroxine (T4) (1) is a hormone produced by the thyroid gland. The thyroid gland uses iodine, from exogenous sources, to produce L-thyroxine (1), which acts as a precursor of 3,5,3’-triiodothyronine (T3). Individuals with low levels of T4 and T3 can suffer from hypothyroidism. Accordingly, L-thyroxine (1) has been indicated for the treatment of this type of endocrine disorder. Although since 1927 the production of the T4 hormone is carried out in laboratory, short synthetic routes involving mild reaction conditions to obtain this important substance are still of considerable interest. In this work we show our preliminary results toward the synthesis of L-thyroxine (1) employing a route that will use in two steps an efficient and selective diiodination reaction developed in our research group.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0057-2

Referências bibliográficas

• [1] 1 Harington, C. R.; Barger, G. Biochem. J. 1927, 21, 169-183.
• [2] 2 Gallo, R. D. C.; Gebara, K. S.; Muzzi, R. M.; Raminelli, C. J. Braz. Chem. Soc. 2010, 21, 770-774.

Como citar:

Gallo, Rafael D. C.; Frota, Carlise; Raminelli, Cristiano; "Studies toward the synthesis of the L-thyroxine hormone.", p-57-57. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0057-2