Studies in Organocatalysts Synthesis for Direct Aldol Reaction

Studies in Organocatalysts Synthesis for Direct Aldol Reaction

Soares, Bruna Miranda; Aguilar, Andréa Maria

Abstract:

The aldol reaction is one of the most important C-C bond forming reactions in organic synthesis, with a large application in the stereoselective synthesis of highly functionalized natural and synthetic substances. The first intermolecular proline-catalyzed direct aldol reaction was described by List and coworkers in 2000. Since then, the direct aldol reaction of aldehydes with ketones in the presence of a catalytic amount of L-proline and its structural derivatives have been evaluated for use in asymmetric catalytic direct aldol reactions. We will report here our preliminary results on the organocatalysts synthesis which will be applied in direct aldol reaction of aldehydes with ketones in aqueous media.

The aldol reaction is one of the most important C-C bond forming reactions in organic synthesis, with a large application in the stereoselective synthesis of highly functionalized natural and synthetic substances. The first intermolecular proline-catalyzed direct aldol reaction was described by List and coworkers in 2000. Since then, the direct aldol reaction of aldehydes with ketones in the presence of a catalytic amount of L-proline and its structural derivatives have been evaluated for use in asymmetric catalytic direct aldol reactions. We will report here our preliminary results on the organocatalysts synthesis which will be applied in direct aldol reaction of aldehydes with ketones in aqueous media.

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DOI: 10.5151/chempro-14bmos-R0252-1

Referências bibliográficas

• [1] 1 Dias, L. C., Aguilar, A. M. Chem. Soc. Rev. 2008, 27, 451.
• [2] 2 List, B., Lerner, R. A., Barbas, C. F., III J. Am. Chem. Soc. 2000, 122, 2395.
• [3] 3 Trost, B. M, Brindle, C. S. Chem. Soc. Rev. 2010, 39, 1600.
• [4] 4 a) Rosen, T.; Chu, D. T. W.; Lico, I. M.; Fernandes, P. B.; Marsh, K.; Shen, L.; Cepa, V. G.; Pernet, A. G. J. Med. Chem. 1988, 31, 1598. b) Filosa, R.; Holder, C.; Auberson, Y. P. Tetrahedron Lett. 2006, 47, 8929.

Como citar:

Soares, Bruna Miranda; Aguilar, Andréa Maria; "Studies in Organocatalysts Synthesis for Direct Aldol Reaction", p-252-252. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0252-1