Simple preparation of new piperidine derivatives as AChE inhibitors for pest control

Simple preparation of new piperidine derivatives as AChE inhibitors for pest control

Méndez, Leonor Yamile Vargas; Kouznetsov, Vladimir V.

Abstract:

The use of synthetic insecticides in agriculture over the years has resulted in the development of resistance in insect pest populations and environmental problems. Therefore, it is highly desirable to develop new selective insecticidal agents based on natural products. Piperidine alkaloids occur widely in plants as well as in the animal kingdom. Due to their great diversity in biological and pharmacological activities, piperidine alkaloids and synthetic piperidines containing various substitution patterns are considered interesting target structures for pesticides development. A major use of AChE inhibitors takes place in agriculture where they are used for the control of insects and some other arthropod pests. Insecticidal activity is based on the overstimulation of the cholinergic system in the insect. Based on these facts and the previous results obtained by our group, we decided to address the design and synthesis of new piperidine molecules series as possible AChEIs.

The use of synthetic insecticides in agriculture over the years has resulted in the development of resistance in insect pest populations and environmental problems. Therefore, it is highly desirable to develop new selective insecticidal agents based on natural products. Piperidine alkaloids occur widely in plants as well as in the animal kingdom. Due to their great diversity in biological and pharmacological activities, piperidine alkaloids and synthetic piperidines containing various substitution patterns are considered interesting target structures for pesticides development. A major use of AChE inhibitors takes place in agriculture where they are used for the control of insects and some other arthropod pests. Insecticidal activity is based on the overstimulation of the cholinergic system in the insect. Based on these facts and the previous results obtained by our group, we decided to address the design and synthesis of new piperidine molecules series as possible AChEIs.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0250-2

Referências bibliográficas

• [1] 1 Houghton, P. J.; Ren, Y. e Howes, M.-J. Nat. Prod. Rep. 2006, 23,181.
• [2] 2 Kouznetsov, V.V.; Vargas Méndez, L.Y. e Muñoz Acevedo, A. Lett. Drug Des. Disc. 2010, 7, 710.
• [3] 3 Ellman, G. L.; Courtney, D.; Andres, V. Jr. e Featherstone, R. M. Biochem. Pharmacol. 1961, 7, 88.

Como citar:

Méndez, Leonor Yamile Vargas; Kouznetsov, Vladimir V.; "Simple preparation of new piperidine derivatives as AChE inhibitors for pest control", p-250-251. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0250-2