Search for an enzymatic approach to achieve the enantiomeric enrichment of b-borylated carboxylic esters

Search for an enzymatic approach to achieve the enantiomeric enrichment of b-borylated carboxylic esters

Reis, Joel S.; Andrade, Leandro H.

Abstract:

Lipases are the most used enzymes in organic chemistry. Their ability of enantiomers recognition by these biocatalysts represents a useful tool to synthesis of enantiomerically enriched compounds. Additionally, boron-containing compounds have increased the interest of scientists for being important building blocks of bioactive substances. The organoboron compounds are employed mainly in the Suzuki-Miyaura cross-coupling reactions. Herein, we are focused on development of an enzymatic way to enrich enantiomerically boroncontaining carboxylic esters, catalyzed by lipases.

Lipases are the most used enzymes in organic chemistry. Their ability of enantiomers recognition by these biocatalysts represents a useful tool to synthesis of enantiomerically enriched compounds. Additionally, boron-containing compounds have increased the interest of scientists for being important building blocks of bioactive substances. The organoboron compounds are employed mainly in the Suzuki-Miyaura cross-coupling reactions. Herein, we are focused on development of an enzymatic way to enrich enantiomerically boroncontaining carboxylic esters, catalyzed by lipases.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0101-1

Referências bibliográficas

• [1] 1 Faber, K. Biotransformations in Organic Chemistry, Springer-Verlag, Berlin, 5th Ed., 2004.
• [2] 2 Hall, D. G., Boronic Acids: Preparation, Aplications in Organic Synthesis and Medicine. Wiley-VHC: Weinheim, 2005.
• [3] 3 Miyaura, N.; Suzuki, A. Chem. Rev. 1995, 95, 2457-2483.
• [4] 4 Mun, S.; Lee, J.; Yun, J. Org. Lett. 2006, 8, 4887-4889.

Como citar:

Reis, Joel S.; Andrade, Leandro H.; "Search for an enzymatic approach to achieve the enantiomeric enrichment of b-borylated carboxylic esters", p-101-101. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0101-1