Screening of microorganisms for ω-transaminase activity

Screening of microorganisms for ω-transaminase activity

Vechia, Luciana Dalla; Lopes, Raquel de Oliveira; Machado, Thelma de Barros; Leal, Ivana Correa Ramos; Miranda, Leandro Soter de M. e; Souza, Rodrigo Octavio Mendonça Alves de

Abstract:

Transaminases (TA) are pyridoxal phosphate dependent enzymes which are capable of transferring amino groups to achiral ketones. TA´s can be used for asymmetric synthesis of amines and also for kinetic resolution of racemic amines. The aim of this work is to screen microorganisms for their _-TA activity for the kinetic resolution of 1- rac-phenylethylamine (Figure 1).

Transaminases (TA) are pyridoxal phosphate dependent enzymes which are capable of transferring amino groups to achiral ketones. TA´s can be used for asymmetric synthesis of amines and also for kinetic resolution of racemic amines. The aim of this work is to screen microorganisms for their _-TA activity for the kinetic resolution of 1- rac-phenylethylamine (Figure 1).

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DOI: 10.5151/chempro-14bmos-R0116-2

Referências bibliográficas

• [1] 1 Koszelewski, D. et al. Trends Biotechnol., 2010, 28, 324.
• [2] 2 Clay, D. et al. Tetrahedron: Asym., 2010, 21, 2005.

Como citar:

Vechia, Luciana Dalla; Lopes, Raquel de Oliveira; Machado, Thelma de Barros; Leal, Ivana Correa Ramos; Miranda, Leandro Soter de M. e; Souza, Rodrigo Octavio Mendonça Alves de; "Screening of microorganisms for ω-transaminase activity", p-116-116. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0116-2