SCNS. 12. Effects of trimetazidine on pilocarpine-induced convulsions in mice: behavioral changes and glutamatergic system modulation

SCNS. 12. Effects of trimetazidine on pilocarpine-induced convulsions in mice: behavioral changes and glutamatergic system modulation

PINHEIRO, T.F.M.; LEMOS, J.C.; BEZERRA, M.M.; AGUIAR, L.M.V.; FILHO, G.C.

Abstract:

Epilepsy is one of the most common and serious neurological conditions, affecting more than 50 million people worldwide. The current clinically available antiepileptic drugs are associated with a variety of side-effects and chronic toxicity. Adverse effects associated with these agents are the main limitation for their long-term use. Therefore, the development of new antiepileptic agent with improved efficacy and minimal adverse effects is very important. Trimetazidine (TMZ) is a lipophilic piperazine derivative, a drug of interest in ischemic diseases. It has demonstrated anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties in various experimental animal models. The aim of this study was to investigate the antioxidant effect of trimetazidine on pilocarpine-induced seizures in mice.

Epilepsy is one of the most common and serious neurological conditions, affecting more than 50 million people worldwide. The current clinically available antiepileptic drugs are associated with a variety of side-effects and chronic toxicity. Adverse effects associated with these agents are the main limitation for their long-term use. Therefore, the development of new antiepileptic agent with improved efficacy and minimal adverse effects is very important. Trimetazidine (TMZ) is a lipophilic piperazine derivative, a drug of interest in ischemic diseases. It has demonstrated anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties in various experimental animal models. The aim of this study was to investigate the antioxidant effect of trimetazidine on pilocarpine-induced seizures in mice.

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DOI: 10.5151/isnm-sine17

Como citar:

PINHEIRO, T.F.M.; LEMOS, J.C.; BEZERRA, M.M.; AGUIAR, L.M.V.; FILHO, G.C.; "SCNS. 12. Effects of trimetazidine on pilocarpine-induced convulsions in mice: behavioral changes and glutamatergic system modulation", p-22-22. In: In I International Symposium in Neuroscience Meeting, 2013 [Blucher Neuroscience Proceedings n.1 v.1]. São Paulo: Blucher, 2014.
ISSN 2357772x, DOI 10.5151/isnm-sine17