SCNS. 11. Effects of ritalin® (methylphenidate hydrochloride) on locomotor activity and lipid peroxidation in pilocarpine-induced status epilepticus in young rats

SCNS. 11. Effects of ritalin® (methylphenidate hydrochloride) on locomotor activity and lipid peroxidation in pilocarpine-induced status epilepticus in young rats

LINHARES, M.I.A.; SOUZA, A.G.A.; SOUZA, L.M.F.B.; AGUIAR, L.M.V.B.; FONTELES, M.M.F.

Abstract:

Attention deficit hyperactivity disorder (ADHD) is a neuropsychiatric disorder that impairs social, academic and occupational activities of children, adolescents and adults. Children with epilepsy have a higher incidence of psychiatric comorbidities, especially ADHD. This association between epilepsy and ADHD is still poorly understood. The Methylphenidate (MPH) is a psychostimulant most used in Brazil to treat ADHD, and there is evidence that the MPH decreases the seizure threshold and that its use can result in the occurrence of seizures. Thus, the purpose of this study was investigate the potential pro-oxidant effects of MPH determining levels of acid reactive substances to thiobarbituric acid (TBARS) after the induction of status epilepticus (SE) by pilocarpine model.

Attention deficit hyperactivity disorder (ADHD) is a neuropsychiatric disorder that impairs social, academic and occupational activities of children, adolescents and adults. Children with epilepsy have a higher incidence of psychiatric comorbidities, especially ADHD. This association between epilepsy and ADHD is still poorly understood. The Methylphenidate (MPH) is a psychostimulant most used in Brazil to treat ADHD, and there is evidence that the MPH decreases the seizure threshold and that its use can result in the occurrence of seizures. Thus, the purpose of this study was investigate the potential pro-oxidant effects of MPH determining levels of acid reactive substances to thiobarbituric acid (TBARS) after the induction of status epilepticus (SE) by pilocarpine model.

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DOI: 10.5151/isnm-sine16

Como citar:

LINHARES, M.I.A.; SOUZA, A.G.A.; SOUZA, L.M.F.B.; AGUIAR, L.M.V.B.; FONTELES, M.M.F.; "SCNS. 11. Effects of ritalin® (methylphenidate hydrochloride) on locomotor activity and lipid peroxidation in pilocarpine-induced status epilepticus in young rats", p-21-21. In: In I International Symposium in Neuroscience Meeting, 2013 [Blucher Neuroscience Proceedings n.1 v.1]. São Paulo: Blucher, 2014.
ISSN 2357772x, DOI 10.5151/isnm-sine16