Abstract:

Psychiatric disorders, including depression, are among the leading causes of disability worldwide. In this context, research about new pathways involved in the pathophysiology of this mental disorder with the search of new targets for the treatment of this disorder has been widely studied. Studies confirm that the increased levels of nitrite are directly related to depression, based on this hypothesis we consider that the administration of organic nitrites can accentuate the depressive-like behavior in an experimental model.