Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

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Regiospecific synthesis of 3-bromo-2-(phenylsulfanyl)pyridine derivatives.

Cañete, Álvaro ; Maldonado, Christel ; Tapia, Ricardo A. ;

Abstract:

New approaches toward the synthesis of sulfanylpyridine derivatives have received considerable attention due to their interesting biological properties that include antibacterial, pesticidal, acaricidal and antifungal activities. Strategies for more selective synthesis of pyridine derivatives have been focused on the use of metalcatalyzed methods. In this context, we considered it convenient to study thermally SNAr reaction between 3-bromo-2- chloropyridine and thiophenol derivatives using different bases without a metal catalyst.

Abstract:

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Palavras-chave: pyridines, thiols, halogen substitution,

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DOI: 10.5151/chempro-14bmos-R0141-1

Referências bibliográficas
  • [1] 1 Srisook, E.; Chi, D. Bull. Korean Chem. Soc. 2004, 25(6), 895.
  • [2] 2(a) Kuwada, Y.; Meguro, K.; Sato, Y.; Fugono, T. Ger Offen 1975, 2,435,025; (b) Kuwada, Y.; Meguro, K.; Sato, Y.; Fugono, T. Chem Abstr. 1975, 82, 15625
  • [3] 3 (a) Ouali, A.; Spindler, J.F.; Cristau, H.J.; Taillefera, M. Adv. Synth. Catal. 2006, 348, 499. (b) Stroup, B.W.; Szlennik, P.V.; Forster, C. J.; . Serrano- Wu, M.H. Org. Lett. 2007, 9(10), 2039. (c) Klapars, A.; Huang, X.; Buchwald S.L.A. J. Am. Chem. Soc. 2002, 124, 7421. (d) Verma, A. Singh, J. Chaundhary, R. Tetrahedron lett. 2007, 48, 7199.
  • [4] 4 Carver, D.R.; Komin, A.P.; Hubbard, J.S.; Wolfe, J.F. J. Org. Chem. 1981, 46, 29
  • [5] 5 Lefour, J.M.; A. Loupy, Tetrahedron 1978, 34, 2597.
Como citar:

Cañete, Álvaro; Maldonado, Christel; Tapia, Ricardo A.; "Regiospecific synthesis of 3-bromo-2-(phenylsulfanyl)pyridine derivatives.", p. 141 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0141-1

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