Quinonoid and phenazine compounds: synthesis of new antimycobacterial prototypes

Quinonoid and phenazine compounds: synthesis of new antimycobacterial prototypes

Carneiro, Paula F.; Pinto, Maria do Carmo F.R.; Coelho, Tatiane S.; Pinto, Antonio V.; Moura, Kelly C.G.; Silva, Pedro A. da; Júnior, Eufrânio N. da Silva

Abstract:

Tuberculosis (TB) is a very aggressive disease caused by Mycobacterium tuberculosis (MT) and still represents nowadays a cause of globally death. Recently, our research group has investigated the antitumor, trypanocidal and antimycobacterial activity of a large number of compounds obtained from lapachol (1). In this context, we present the synthesis and evaluation of phenazine compounds obtained from diverse quinones against MT pansusceptible and resistant strains.

Tuberculosis (TB) is a very aggressive disease caused by Mycobacterium tuberculosis (MT) and still represents nowadays a cause of globally death. Recently, our research group has investigated the antitumor, trypanocidal and antimycobacterial activity of a large number of compounds obtained from lapachol (1). In this context, we present the synthesis and evaluation of phenazine compounds obtained from diverse quinones against MT pansusceptible and resistant strains.

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DOI: 10.5151/chempro-14bmos-R0224-1

Referências bibliográficas

• [1] 1 Fears, R.; Kaufmann, S.; Meulen, V.; Zumla, A. Tuberculosis 2010, 90, 182.
• [2] 2 da Silva Júnior, E. N.; de Souza, M. C. B. V.; Pinto, A. V.; Pinto, M. C. F. R.; Goulart, M. O. F.; Barros, F. W. A.; Pessoa, C.; Costa-Lotufo, L. V.; Montenegro, R. C.; de Moraes, M. O.; Ferreira, V. F. Bioorg. Med. Chem. 2007, 15, 7035.
• [3] 3 da Silva Júnior, E. N.; Menna-Barreto, R. F. S.; Pinto, M. C. F. R.; Silva, R. S. F.; Teixeira, D. V.; de Souza, M. C. B. V.; de Simone, C. A.; de Castro, S. L.; Ferreira, V. F.; Pinto, A. V. Eur. J. Med. Chem. 2008, 43, 1774.
• [4] 4 Coelho T. A.; Silva, R. S. F.; Pinto, A. V.; Pinto, M. C. F. R. Scaini, C. J.; Moura, K. C. G.; da Silva, P. A. Tuberculosis 2010, 90, 293.

Como citar:

Carneiro, Paula F.; Pinto, Maria do Carmo F.R.; Coelho, Tatiane S.; Pinto, Antonio V.; Moura, Kelly C.G.; Silva, Pedro A. da; Júnior, Eufrânio N. da Silva; "Quinonoid and phenazine compounds: synthesis of new antimycobacterial prototypes", p-224-224. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0224-1