Abstract:

Hantzsch multicomponent reaction has been recognized as important synthetic method to access the 1,4-dihydropyridines (1,4-DHPs) with high atomic economy. These compounds exhibit a widerange of biological activities, specially as calcium channel blockers and useful drugs for the treatment of heart diseases. Polyhydroquinolines (PHQs) derivatives are structurally related compounds that can be obtained via a non-symmetrical Hantzsch reaction. The utilization of Lewis acid catalysts in these syntheses is an alternative to surpass drawbacks such as long reaction times, harsh conditions and low yields. Moreover, heterogeneous catalysts are of easy handling and fast isolation from the reaction, minimizing additional work-up procedures. In the present work we describe the preparation of a novel In/SiO2 composite and its application as heterogeneous Lewis acid catalyst in a solventless multicomponent Hantzsch reaction.