Novel Photoactive N-Heterocycles Bearing a Benzoxazole Moiety: Synthesis and Photophysical study

Novel Photoactive N-Heterocycles Bearing a Benzoxazole Moiety: Synthesis and Photophysical study

Affeldt, Ricardo F.; Russowsky, Dennis; Rodembusch, Fabiano S.

Abstract:

The 2-(2’-hydroxyphenyl)benzoxazole (HBO) has been receiving considerable attention during the past decades concerning its application as highintense fluorescent probe. On the other hand, 1,4- dihydropyridines (1,4-DHP) are small molecules recognized for their pronounced bioactivity as calcium channel blockers. Structurally, the 1,4- DHPs are biommimetic analogues of the NADH coenzyme, which has also application as fluorescent probe in biological fermentations. Herein, we describe the synthesis and photophysical study of new 1,4-DHPs bearing the fluorescent HBO moiety.

The 2-(2’-hydroxyphenyl)benzoxazole (HBO) has been receiving considerable attention during the past decades concerning its application as highintense fluorescent probe. On the other hand, 1,4- dihydropyridines (1,4-DHP) are small molecules recognized for their pronounced bioactivity as calcium channel blockers. Structurally, the 1,4- DHPs are biommimetic analogues of the NADH coenzyme, which has also application as fluorescent probe in biological fermentations. Herein, we describe the synthesis and photophysical study of new 1,4-DHPs bearing the fluorescent HBO moiety.

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DOI: 10.5151/chempro-14bmos-R0156-1

Referências bibliográficas

• [1] 1(a) Abou-Zied, O.K. Chem. Phys. 2007, 337, 1. (b) Demchenko, A.P. et al. J. Fluor. 2010, 20, 1099.
• [2] 2 Bossert, F. et al. Angew. Chem. Int. Ed. Engl. 1981, 20, 762.
• [3] 3 Affeld, R.F.; Russowsky, D. XXXI RASBQ, 2008, Águas de Lindóia/SP.

Como citar:

Affeldt, Ricardo F.; Russowsky, Dennis; Rodembusch, Fabiano S.; "Novel Photoactive N-Heterocycles Bearing a Benzoxazole Moiety: Synthesis and Photophysical study", p-156-156. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0156-1