New Palladacycles Derived Acylhydrazones and Hydrazones as Pre-catalyst in Mirozoki-Heck Coupling and Oxyarylations

New Palladacycles Derived Acylhydrazones and Hydrazones as Pre-catalyst in Mirozoki-Heck Coupling and Oxyarylations

Pinho, Vagner D.; Leão, Raquel Ana. C.; Coelho, Arthur Serpa; Kümmerle, Arthur Eugen; Costa, Paulo R. R.

Abstract:

Palladacycle pre-catalyst are considered to be a source of palladium nanoparticles formed in situ and have been used with success, with low catalytic loading, in several coupling reactions. Herein we report the preparation of palladacycles 1 and 2 through electrophilic C-H activation of acylhydrazones and hydrazones by reacting them with Li2PdCl4 in methanol. Although some hydrazone-based palladacycle are known in the literature. we describe for the first time their use as catalyst in Heck-Mizoroki arylation and oxyarylation reactions.

Palladacycle pre-catalyst are considered to be a source of palladium nanoparticles formed in situ and have been used with success, with low catalytic loading, in several coupling reactions. Herein we report the preparation of palladacycles 1 and 2 through electrophilic C-H activation of acylhydrazones and hydrazones by reacting them with Li2PdCl4 in methanol. Although some hydrazone-based palladacycle are known in the literature. we describe for the first time their use as catalyst in Heck-Mizoroki arylation and oxyarylation reactions.

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DOI: 10.5151/chempro-14bmos-R0072-2

Referências bibliográficas

• [1] 1 Botella, L.; Nájera, C., J. Org. Chem.. 2005, 70, 4360.
• [2] 2 Le Bras, J.; Muzart, J., Chem. Rev. 2011,111,1170.
• [3] 3Leão, R. A. C.; Pinho, V. D.; Coelho, A. S.; Buarque, C. B.; Moraes, P. F.; Alonso, D. A.; Nájera, C.; Costa, P. R. R. Eur. J. Org. Chem. in press.

Como citar:

Pinho, Vagner D.; Leão, Raquel Ana. C.; Coelho, Arthur Serpa; Kümmerle, Arthur Eugen; Costa, Paulo R. R.; "New Palladacycles Derived Acylhydrazones and Hydrazones as Pre-catalyst in Mirozoki-Heck Coupling and Oxyarylations", p-72-72. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0072-2