New molecules containing the 1,2,3-triazole moiety as potential HIV-1 Nef inhibitors.

New molecules containing the 1,2,3-triazole moiety as potential HIV-1 Nef inhibitors.

Corrêa, Lucília Zeymer Alves; Salvador, Carlos Eduardo M.; Andrade, Carlos Kleber Z.

Abstract:

The HIV-1 protein Nef is responsible for the degradation of the cell membrane protein CD4. Ikarugamycin (Figure 1) is a known drug that binds to Nef and blocks its activity. Based on calculations of the interaction energy between the drug Ikarugamycin and Nef protein, we proposed new molecules with Nef inhibition potential (Figure 2). These new molecules have lower interaction energy values with Nef protein than the drug Ikarugamycin itself. This work describes a short and efficient synthetic route for the target molecules.

The HIV-1 protein Nef is responsible for the degradation of the cell membrane protein CD4. Ikarugamycin (Figure 1) is a known drug that binds to Nef and blocks its activity. Based on calculations of the interaction energy between the drug Ikarugamycin and Nef protein, we proposed new molecules with Nef inhibition potential (Figure 2). These new molecules have lower interaction energy values with Nef protein than the drug Ikarugamycin itself. This work describes a short and efficient synthetic route for the target molecules.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0249-1

Referências bibliográficas

• [1] 1 Lama, J. Curr. HIV Res. 2003, 1, 167.

Como citar:

Corrêa, Lucília Zeymer Alves; Salvador, Carlos Eduardo M.; Andrade, Carlos Kleber Z.; "New molecules containing the 1,2,3-triazole moiety as potential HIV-1 Nef inhibitors.", p-249-249. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0249-1