Abstract:

Angelman syndrome is a complex neurogentetic disorder characterized by intellectual disability, problems with movement and balance, frequent laughter or smiling and other features. The Angelman syndrome is a classic example of deletion or inactivation of genes on the chromosome 15, most commonly by deletion of a segment of that chromosome. Developmental delays are first noted at around six months age until after one year, and it can take several years before the correct clinical diagnosis is performed.