Multicomponent Povarov reaction catalyzed by NbCl5.

Multicomponent Povarov reaction catalyzed by NbCl5.

Silva, Bruno Henrique Sacoman Torquato da; Martins, Lucas Michelão; Silva-Filho, Luiz Carlos da

Abstract:

Recent studies in literature show efficiency of tetrahydroquinolines derivatives (1) as an anticancer agent, acting in the inhibition of certain enzymes that are essential in the cellular division. Tetrahydroquinolines derivatives also showed activity in the treatment of Alzheimer's Disease by inhibiting the enzyme acetylcholinesterase, an enzyme needed for nerve impulse transmission and responsible for the degradation of acetilchlorine. Tetrahydroquinolines derivatives can be synthesized from the Multicomponent Povarov reaction (MCR) in the presence of different catalysts (GdCl3, SbCl3, SmI2, VCl3 and others).

Recent studies in literature show efficiency of tetrahydroquinolines derivatives (1) as an anticancer agent, acting in the inhibition of certain enzymes that are essential in the cellular division. Tetrahydroquinolines derivatives also showed activity in the treatment of Alzheimer's Disease by inhibiting the enzyme acetylcholinesterase, an enzyme needed for nerve impulse transmission and responsible for the degradation of acetilchlorine. Tetrahydroquinolines derivatives can be synthesized from the Multicomponent Povarov reaction (MCR) in the presence of different catalysts (GdCl3, SbCl3, SmI2, VCl3 and others).

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0112-1

Referências bibliográficas

• [1] 1 (a) Gore, V. K.; et al. Bioorg. Med. Chem . Lett. 2010, 20, 3573.
• [2] 2 (b) Schiemann, K.; et al. Bioorg. Med. Chem . Lett. 2010, 20, 1491; (c) Camps, P.; et al. J. Med. Chem. 2009, 52, 5365.
• [3] 2 (a) Ma, Y.; et al. J. Org. Chem. 2009, 64, 6462.; (b) Zhou, Z.; et al. Eur. J. Org. Chem. 2007, 5265.; (c) Semwal, A.; et al. Synth, Communs. 2006. 36, 227. (d) Mahajan, D.; et al. Tetrahedron Lett. 2006, 7919.

Como citar:

Silva, Bruno Henrique Sacoman Torquato da; Martins, Lucas Michelão; Silva-Filho, Luiz Carlos da; "Multicomponent Povarov reaction catalyzed by NbCl5.", p-112-112. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0112-1