Microwave assisted synthesis of biologically relevant selenosemicarbazones

Microwave assisted synthesis of biologically relevant selenosemicarbazones

Pizzo, Chiara; Wipf, Peter; Mahler, Graciela

Abstract:

The synthesis of compounds containing selenium has caught much attention due to their biological and pharmaceutical properties. It has been widely reported that organoselenium compounds can be used as antioxidant, antiinflammatory, antibacterial, antiviral, and antitumor agents. Cruzipain is the native enzyme responsible for the mayor proteolytic activity in all stages of Trypanosoma cruzi parasite, the causative agent of Chagas disease. Thiosemicarbazones have been developed as reversible cruzipain inhibitors. In this order, since selenium shares similar electronic properties with sulfur, an isosteric replacement could turn the selenocarbonyl group into more nucleophilic specie compared to thiocarbonyl moiety and consequently be active against cruzipain.

The synthesis of compounds containing selenium has caught much attention due to their biological and pharmaceutical properties. It has been widely reported that organoselenium compounds can be used as antioxidant, antiinflammatory, antibacterial, antiviral, and antitumor agents. Cruzipain is the native enzyme responsible for the mayor proteolytic activity in all stages of Trypanosoma cruzi parasite, the causative agent of Chagas disease. Thiosemicarbazones have been developed as reversible cruzipain inhibitors. In this order, since selenium shares similar electronic properties with sulfur, an isosteric replacement could turn the selenocarbonyl group into more nucleophilic specie compared to thiocarbonyl moiety and consequently be active against cruzipain.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0067-1

Referências bibliográficas

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Como citar:

Pizzo, Chiara; Wipf, Peter; Mahler, Graciela; "Microwave assisted synthesis of biologically relevant selenosemicarbazones", p-67-67. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0067-1