Improved procedure for the a-Arylation of chromanones by O-Protected ortho-Bromophenols

Improved procedure for the a-Arylation of chromanones by O-Protected ortho-Bromophenols

Domingos, Jorge L. O.; Alonso, Diego; Nájera, Carmem; Costa, Paulo R. R.

Abstract:

In recent years some procedures for the a-arylation of ketones appeared in the literature, allowing the formation of secondary, tertiary and even quaternary centers. However, only few examples on the use of ortho-substituted arylhalides have been described. As part of a project aiming the synthesis of isoflavonoids, we report herein a study on the α- arylation of chromanone 1a and deoxi-chromanone 1b by ortho-bromophenol derivatives 2a-c.

In recent years some procedures for the a-arylation of ketones appeared in the literature, allowing the formation of secondary, tertiary and even quaternary centers. However, only few examples on the use of ortho-substituted arylhalides have been described. As part of a project aiming the synthesis of isoflavonoids, we report herein a study on the α- arylation of chromanone 1a and deoxi-chromanone 1b by ortho-bromophenol derivatives 2a-c.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0093-1

Referências bibliográficas

• [1] 1 Bellina, F., Rossi, R., Eur. J.Org. Chem. 2010, 1339 and references cited.
• [2] 2 Botella, L.; Nájera, C., J. Org. Chem.. 2005, 70, 4360.

Como citar:

Domingos, Jorge L. O.; Alonso, Diego; Nájera, Carmem; Costa, Paulo R. R.; "Improved procedure for the a-Arylation of chromanones by O-Protected ortho-Bromophenols", p-93-93. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0093-1