Identification of N-acylhydrazones as potent TNF inhibitors

Identification of N-acylhydrazones as potent TNF inhibitors

Gomes, Paulo A. T. M.; Coêlho, Luca Cunha D.; Moreira, Diogo R. M.; Cardoso, Marcos V. O.; Cavalcanti, Suellen M. T.; Filho, Gevanio B. de O.; Silva, Elany B.; Abraham, Lawrence J.; Leite, Ana C. L.

Abstract:

Modulation of the immune system is an emerging concept in the control of tumor growth. Among the anticancer and immunomodulatory drug candidates, that have entered into clinical trials, the majority are analogues of thalidomide (Thl), such as lenalidomide (Revlimid, CC-5013) and ACTIMID (CC-4047). Given this promising outlook, the strategy of molecular hybridization using phthalimide as a pharmacophoric fragment has figured prominently in recent research and has given rise to many successful outcomes. Bearing in mind the pharmacophore groups previously described in literature and its structural requirements, we describe here the initial identification of N-acylhydrazone-based immunomodulatory agentes.

Modulation of the immune system is an emerging concept in the control of tumor growth. Among the anticancer and immunomodulatory drug candidates, that have entered into clinical trials, the majority are analogues of thalidomide (Thl), such as lenalidomide (Revlimid, CC-5013) and ACTIMID (CC-4047). Given this promising outlook, the strategy of molecular hybridization using phthalimide as a pharmacophoric fragment has figured prominently in recent research and has given rise to many successful outcomes. Bearing in mind the pharmacophore groups previously described in literature and its structural requirements, we describe here the initial identification of N-acylhydrazone-based immunomodulatory agentes.

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DOI: 10.5151/chempro-14bmos-R0214-2

Referências bibliográficas

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Como citar:

Gomes, Paulo A. T. M.; Coêlho, Luca Cunha D.; Moreira, Diogo R. M.; Cardoso, Marcos V. O.; Cavalcanti, Suellen M. T.; Filho, Gevanio B. de O.; Silva, Elany B.; Abraham, Lawrence J.; Leite, Ana C. L.; "Identification of N-acylhydrazones as potent TNF inhibitors", p-214-214. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0214-2